Myeloablative Consolidation Therapy and Tandem Autologous Stem Cell Rescue in Patients With High-Risk Neuroblastoma

ConditionNeuroblastoma
Trial statusRecruiting
Trial phasePhase 2
Trial typeInterventional
Biological sexAll
AgeUp to 30
SponsorMasonic Cancer Center, University of Minnesota

About this trial

This is a phase II single center study to administer two courses of myeloablative consolidation chemotherapy each followed by an autologous peripheral blood stem cell (PBSC) rescue in patients with high-risk neuroblastoma who have completed induction chemotherapy (independent of this study). Ideally, patients should begin consolidation chemotherapy no later than 8 weeks after the start of Induction Cycle #5; however it is strongly recommended to begin consolidation within 4-6 weeks after the start of Induction Cycle #5.

Eligibility criteria

Qualifiers

Less than 30 years of age at diagnosis of neuroblastoma

End of Induction disease evaluation demonstrating CR, PR, MR or SD

Hematopoietic Recovery from last induction course of chemotherapy

No uncontrolled infection

Disqualifiers

None

Trial design

Treatments tested in this trial

  • Thiotepa
  • Cyclophosphamide
  • Melphalan
  • Etoposide
  • Carboplatin
  • Autologous Stem Cell Infusion
  • Granulocyte colony stimulating factor

Treatment groups

12 Participants
are divided into 1 treatment group