The purpose of this study is to find out whether N10 chemotherapy is a safe and effective treatment for children with high-risk neuroblastoma.
Diagnosis of NB as defined by histopathology, BM metastases plus high urine catecholamine levels, or positivity in MIBG scan.
HR-NB, defined as MYCN-amplified stage L2/M/MS at any age and stage M in patients >18 months old.
No more than one prior cycle of HR-NB chemotherapy
Age <19 years.
Severe dysfunction of major organs, i.e., renal, cardiac, hepatic, neurologic, pulmonary, hematologic, or gastrointestinal toxicity >/= to grade 3
Inability to comply with protocol requirements
Pregnancy