Nasal Obstruction With Oxymetazoline and Corticosteroids

Trial statusRecruiting
Trial phasePhase 2
Trial typeInterventional
Biological sexAll
Age18+
SponsorWashington University School of Medicine

About this trial

This study aims to examine the efficacy and safety of commination oxymetazoline/intranasal steroids for long-term management of chronic nasal obstruction that is recalcitrant to the current standard of care. The investigators hypothesize that combination treatment with oxymetazoline and intranasal corticosteroid spray will provide a larger reduction in nasal obstruction than intranasal corticosteroid alone for patients suffering from chronic nasal obstruction, and there will not be occurrences of rhinitis medicamentosa.

Eligibility criteria

Qualifiers

males and females ages 18 years or older

have a history of nasal obstruction

have failed a trial of topical steroids (that included at least 1 month of daily use)

ability to read, write, and understand English

Disqualifiers

Any history of sinonasal mass/tumor

Any history of nasal polyps

a known history of chronic sinusitis

an allergy to oxymetazoline

Trial design

Treatments tested in this trial

  • Oxymetazoline Nasal Spray
  • Budesonide nasal spray

Treatment groups

80 Participants
are divided into 2 treatment groups