About this trial
This study aims to examine the efficacy and safety of commination oxymetazoline/intranasal steroids for long-term management of chronic nasal obstruction that is recalcitrant to the current standard of care. The investigators hypothesize that combination treatment with oxymetazoline and intranasal corticosteroid spray will provide a larger reduction in nasal obstruction than intranasal corticosteroid alone for patients suffering from chronic nasal obstruction, and there will not be occurrences of rhinitis medicamentosa.
Eligibility criteria
Qualifiers
males and females ages 18 years or older
have a history of nasal obstruction
have failed a trial of topical steroids (that included at least 1 month of daily use)
ability to read, write, and understand English
Disqualifiers
Any history of sinonasal mass/tumor
Any history of nasal polyps
a known history of chronic sinusitis
an allergy to oxymetazoline
Trial design
Treatments tested in this trial
- Oxymetazoline Nasal Spray
- Budesonide nasal spray