Neostigmine and Glycopyrrolate for the Treatment of Headache After Dural Puncture
ConditionPost-Dural Puncture Headache
Trial statusRecruiting
Trial phasePhase 2
Trial typeInterventional
Biological sexFemale
Age18-54
SponsorMayo Clinic
About this trial
The purpose of this study is to evaluate Neostigmine and Glycopyrrolate to treat post-dural puncture headache (PDPH) to reduce the proportion of postpartum women with a PDPH requiring epidural blood patch (EBP) who developed a PDPH after accidental dural puncture.
Eligibility criteria
Qualifiers
Post-dural puncture headache (PDPH) after documented dural puncture with Tuohy needle during placement of epidural analgesia for labor and no other explanation for headache (HA).
Onset of HA within 72 hours of delivery.
Disqualifiers
Patient refusal.
Visual analog scale (NRS) score < 4.
History of migraine headaches.
Asthma.
Trial design
Treatments tested in this trial
- Neostigmine
- Glycopyrrolate
Treatment groups
18 Participants
are divided into 1 treatment groupSponsors and collaborators
Source ClinicalTrials.gov