Neuroimaging Correlates and Feasibility of Transcranial Magnetic Stimulation (TMS) to Improve Smoking Cessation Outcomes in Veterans With Comorbid PTSD

Trial statusRecruiting
Trial phasePhase 2
Trial typeInterventional
Biological sexAll
Age18-75
SponsorVA Office of Research and Development

About this trial

Tobacco use is the number one preventable cause of the death in the United States, and is high among US Veterans, and those who have experienced trauma are more likely to smoke. Despite the efficacy of current evidence-based treatments for smoking cessation, there is a critical need for alternative treatments. This project seeks to evaluate the feasibility and effectiveness of a smoking cessation treatment for Veterans with posttraumatic stress disorder (PTSD) who smoke. The treatment combines smoking cessation counseling, nicotine replacement therapy (e.g., nicotine gum), and repetitive transcranial magnetic stimulation (rTMS). rTMS is a noninvasive brain stimulation treatment that has been cleared by the Food and Drug Administration for smoking cessation in adults.

Eligibility criteria

Qualifiers

Is a US Veteran

Meets DSM-5 criteria for tobacco use disorder

Is between the ages of 18 and 75

Smokes an average of 10 cigarettes per day for the past 6 months, with carbon monoxide (CO) level > 6 ppm

Disqualifiers

Has had a substance use disorder other than tobacco in the preceding 3 months

Has a history of myocardial infarction in the past 6 months or has another contraindication to NRT

Has a contraindication to TMS or MRI

Personal or family history of a seizures or epilepsy

Trial design

Treatments tested in this trial

  • active repetitive transcranial magnetic stimulation
  • sham repetitive transcranial magnetic stimulation
  • cognitive behavioral therapy for smoking cessation
  • nicotine replacement therapy

Treatment groups

50 Participants
are divided into 2 treatment groups