Non-steroidal Anti-inflammatory Drugs in Pleurodesis
Trial statusRecruiting
Trial phasePhase 2
Trial typeInterventional
Biological sexAll
Age18+
SponsorCentre Hospitalier Universitaire, Amiens
About this trial
Non-steroidal anti-inflammatory drugs (NSAIDs) are recommended in a multimodal pain management to reduce pain intensity and to spare opioid use. However, there is a controversy in its use in pleurodesis surgery as it could block the process of pleurodesis in surgical pneumothorax. In addition, NSAIDs could increase the risk of pneumothorax recurrence.
The investigators hypothesized that NSAIDs are safe during pleurodesis with a better pain management without increasing the risk of pneumothorax reccurence.
Eligibility criteria
Qualifiers
Age≥18-year-old
pneumothorax with an indication of pleurodesis
with or without minimal lung resection
via thoracotomy or thoracoscopy
Disqualifiers
Minor patient
Pregnant, parturient or breast-feeding patient
Severe polytrauma (associated with the presence of a Vittel criterion)
Purulent pleurisy
Trial design
Treatments tested in this trial
- pleurodesis procedures
- KETOPROFEN(RP19583)
- Placebo
Treatment groups
358 Participants
are divided into 2 treatment groupsSponsors and collaborators
Centre Hospitalier Universitaire, Amiens
Lead sponsor
Centre Hospitalier VALENCIENNES
Collaborator
Clinique Victor Pauchet
Collaborator
University Hospital, Rouen
Collaborator
Source ClinicalTrials.gov