Orexin Receptor Antagonism and Sleep in Stimulant Use Disorder

Trial statusRecruiting
Trial phasePhase 2
Trial typeInterventional
Biological sexAll
Age18-65
SponsorThe University of Texas Health Science Center, Houston

About this trial

The purpose of this study is to determine the effects of suvorexant (SUVO), on sleep, stress, and drug craving during early abstinence from stimulants and to determine the effects of treatment (SUVO vs. treatment as usual (TAU)) on post-treatment (Days 13-30) residential program length of stay (LOS) and completion rate.

Eligibility criteria

Qualifiers

Meet Diagnostic and Statistical Manual of Mental Disorders(DSM-5)criteria for primary stimulant use disorder (either cocaine or methamphetamine)

Be fluent in English and able to understand the consent form

Disqualifiers

Have an opioid use disorder of any severity

Have a greater than moderate substance use disorder on any other substance

Undergoing medication-assisted treatment for withdrawal of any substance

Have any medical conditions contraindicating SUVO (e.g., severe pulmonary disease, severe cardiovascular disease or clinically abnormal ECG, severe liver or kidney disease, seizure disorder, or sleep disorder -particularly narcolepsy)

Trial design

Treatments tested in this trial

  • SUVO
  • TAU

Treatment groups

20 Participants
are divided into 2 treatment groups