PeRampanel fOr Status ePilEpticus pRophylaxis Post-cardiac Arrest
Trial statusRecruiting
Trial phasePhase 2
Trial typeInterventional
Biological sexAll
Age18+
SponsorUniversity of California, San Francisco
About this trial
Brain injury is the main cause of death and disability for patients surviving cardiac arrest resuscitation and seizures are diagnosed in up to a third of these patients. The investigators are proposing a pilot randomized placebo-controlled clinical trial to evaluate the safety and feasibility of perampanel use for post-cardiac arrest status epilepticus (PCARSE) prevention after cardiac arrest.
Eligibility criteria
Qualifiers
Age ≥18 years old
Non-traumatic, out-of-hospital cardiac arrest
Comatose on admission - defined as not following commands
Return of spontaneous circulation (ROSC) within less than 45 minutes from the time of cardiac arrest (defined as the time of 911 or EMS (emergency medical services) witnessed arrest)
Disqualifiers
Acute cerebral hemorrhage or infarction
Pregnancy
Prisoner
Severe kidney function impairment with creatinine clearance inferior to 30 ml/min
Trial design
Treatments tested in this trial
- Perampanel
- Placebo
Treatment groups
52 Participants
are divided into 2 treatment groupsSponsors and collaborators
Source ClinicalTrials.gov