Multicentric prospective model-based de-escalation of the elective clinical target volumes (CTV) in radiotherapy of oropharyngeal carcinoma of all stages with the goal to reduce toxicity.
The study investigates the feasibility of this approach as measured by the number of expected out-of-field recurrencies based on the individual patient's state of disease progression and risk factors
Patients with a newly diagnosed (no pre-treatment) squamous cell carcinoma of the oropharynx (i.e. tonsils, base of tongue, oropharyngeal walls, oropharyngeal surface of epiglottis; ICD-10 codes C01, C09, C10), T1-4, N0-3.
Treatment with definitive (chemo) radiotherapy planned, with elective irradiation of the lymph nodes.
Age ≥ 18 years, no upper age limit.
ECOG performance score < 3.
Patients with a newly diagnosed (no pre-treatment) squamous cell carcinoma of the oropharynx (i.e. tonsils, base of tongue, oropharyngeal walls, oropharyngeal surface of epiglottis; ICD-10 codes C01, C09, C10), T1-4, N0-3.
Treatment with definitive (chemo) radiotherapy planned, with elective irradiation of the lymph nodes.
Age ≥ 18 years, no upper age limit.
ECOG performance score < 3.
University of Zurich
Lead sponsor
Insel Gruppe AG, University Hospital Bern
Collaborator
University Hospital, Geneva
Collaborator
Ospedale Regionale Bellinzona e Valli
Collaborator
Réseau Hospitalier Neuchâtelois
Collaborator
Kantonsspital Aarau
Collaborator