Phase 2 Trial of Adaptive Radiotherapy Boost for HNSCC
Trial statusRecruiting
Trial phasePhase 2
Trial typeInterventional
Biological sexAll
Age18+
SponsorH. Lee Moffitt Cancer Center and Research Institute
About this trial
The purpose of the study is to determine if it is feasible to use magnetic resonance imaging (MRI) to adjust a portion of radiation therapy for patients with head and neck squamous cell carcinoma . The technique under study will be used to personalize the study treatment based on response, keeping all treatments within standard of care guidelines.
Eligibility criteria
Qualifiers
Provision of signed and dated informed consent form
Stated willingness to comply with all study procedures and availability for the duration of the study
ECOG performance status of 0, 1
Patients with histologically or cytologically confirmed squamous cell carcinoma of the oral cavity, oropharynx, nasopharynx, hypopharynx, larynx, or unknown primary in the neck.
Disqualifiers
Pregnancy or lactation
Patients who have had prior radiotherapy to the head and neck or prior systemic therapy for the index cancer.
Patients who had undergone definitive surgery for the index cancer.
Patients with distant metastatic disease
Trial design
Treatments tested in this trial
- Intensity-modulated radiotherapy
- Magnetic Resonance Guidance
Treatment groups
35 Participants
are divided into 1 treatment groupSponsors and collaborators
Source ClinicalTrials.gov