Phase II Clinical Study of SHR2554 Tablets Combined With Other Anti-tumor Treatments in Non-small Cell Lung Cancer Subjects

Trial statusRecruiting
Trial phasePhase 2
Trial typeInterventional
Biological sexAll
Age18-75
SponsorJiangsu HengRui Medicine Co., Ltd.

About this trial

Evaluate the safety, tolerability, and objective response rate (ORR) of SHR2554 tablets in combination with other anti-tumor treatments in subjects with locally advanced or metastatic non-small cell lung cancer

Eligibility criteria

Qualifiers

Age range of 18-75 years old (including both ends), gender not limited;

Patients with locally advanced unresectable or metastatic non-small cell lung cancer diagnosed by pathology

ECOG score is 0 or 1

Expected survival period ≥ 12 weeks

Disqualifiers

Having difficulty swallowing or malabsorption syndrome or any other uncontrolled gastrointestinal disease (such as nausea, diarrhea, or vomiting), having undergone gastrectomy or gastric banding surgery, etc

Symptomatic or active central nervous system tumor metastasis

Previously or simultaneously suffering from other malignant tumors

Spinal cord compression that cannot be cured by surgery and/or radiotherapy

Trial design

Treatments tested in this trial

  • SHR2554; SHR-A2102
  • SHR2554; Adabelimumab
  • SHR2554; SHR-1701

Treatment groups

200 Participants
are divided into 3 treatment groups