Phase II Clinical Trial Evaluating the Efficacy and Safety of HRS-7249 and SHR-1918 in Patients With Severe Hypertriglyceridemia at High Risk of Acute Pancreatitis

Trial statusRecruiting
Trial phasePhase 2
Trial typeInterventional
Biological sexAll
Age18-80
SponsorFujian Shengdi Pharmaceutical Co., Ltd.

About this trial

Phase II clinical trial evaluating the efficacy and safety of HRS-7249 and SHR-1918 in patients with severe hypertriglyceridemia at high risk of acute pancreatitis

Eligibility criteria

Qualifiers

Understand the research procedures and methods, voluntarily participate in this trial, and sign the informed consent form in writing;

Male or female aged ≥18 years and <80 years on the day of signing the informed consent form.

Disqualifiers

History of gallstones at the time of screening or previously (except for patients who had their gallbladder removed more than 3 months ago);

Acute pancreatitis that has clinically recovered ≤4 weeks before screening or randomization;

Malignant tumor within 5 years before screening or randomization (except for non-melanoma skin cancer or cervical carcinoma in situ that has been radically treated);

Grade 3/4 heart failure at the time of screening or before randomization;

Trial design

Treatments tested in this trial

  • HRS-7249 injection set
  • SHR-1918 injection set
  • HRS-7249 injection placebo set
  • SHR-1918 injection placebo set

Treatment groups

108 Participants
are divided into 4 treatment groups