Progesterone to Enhance the Efficacy and Success of Expectantly Managed Preterm Severe/Superimposed Preeclampsia

Trial statusRecruiting
Trial phasePhase 2
Trial typeInterventional
Biological sexFemale
Age18-45
SponsorUniversity of Mississippi Medical Center

About this trial

The purpose of this study is to learn if giving 17-hydroxyprogesterone caproate (17 OHPC) to mothers with preeclampsia diagnosed before 34 weeks gestation improves mother and baby outcomes.

Eligibility criteria

Qualifiers

UMMC antepartum patients with preterm PE between 23 0/7ths and 34 0/7ths weeks gestation when initially evaluated

Willing and able to understand study procedures and to provide informed consent

Disqualifiers

>33 weeks gestational age or <23 weeks gestation

Maternal compromise requiring emergent delivery (ongoing placental abruption, DIC, pulmonary edema).

Fetal compromise requiring emergent delivery (fetal bradycardia, recurrent late fetal heart rate decelerations, minimal to absent fetal heart rate variability).

Preterm premature rupture of membranes (PPROM) > 34 weeks gestation;

Trial design

Treatments tested in this trial

  • 17 OHPC

Treatment groups

60 Participants
are divided into 2 treatment groups