R-VRD Followed by Lenalidomide Maintenance in Patients With Waldenstrom's Macroglobulinemia

Trial statusRecruiting
Trial phasePhase 2
Trial typeInterventional
Biological sexAll
Age19+
SponsorKosin University Gospel Hospital

About this trial

A multicenter prospective phase II study of rituximab combined, lenalidomide, dexamethasone followed by lenalidomide maintenance in patients with newly diagnosed Waldenström's macroglobulinemia (Ballondor trial)

Eligibility criteria

Qualifiers

Clinicopathological diagnosis of Waldenstrom's Macroglobulinemia

Patients who meet criteria for treatment using consensus panel criteria from the Second International Workshop on Waldenstrom's macroglobulinemia

Male or female patients aged ≥19 years

Eastern Cooperative Oncology Group (ECOG) performance status 0-2

Disqualifiers

Central nervous system involvement central nervous system (CNS) involvement by Waldenström's macroglobulinemia

Patients who have received rituximab, lenalidomide, or bortezomib

Patients who are allergic or hypersensitive to mouse (murine), chimeric, human or humanized proteins, lenalidomide, bortezomib

Absolute neutrophil count (ANC) <1,000 / μL

Trial design

Treatments tested in this trial

  • Lenalidomide, Bortezomib, Rituximab, Dexamethasone

Treatment groups

54 Participants
are divided into 1 treatment group