RAPid SimPLE Targeted Radiation Treatment for Brain Metastases
ConditionBrain Metastases, Adult
Trial statusRecruiting
Trial phasePhase 2
Trial typeInterventional
Biological sexAll
Age18-100
SponsorBritish Columbia Cancer Agency
About this trial
The aim of the study is to show that rapid, simple targeted radiotherapy to brain metastases with 8 Gy / 1 is non-inferior to 20 Gy / 5 in terms of overall survival for patients with poor prognosis.
Eligibility criteria
Qualifiers
Age ≥ 18
Pathological diagnosis of a non-hematopoietic malignancy
Brain metastases of any size
Any number of untreated or progressing, previously treated brain metastases that can all be contoured and targeted
Disqualifiers
Inability to have a brain MRI
WBRT less than 3 months prior to randomization
Disseminated leptomeningeal carcinomatosis (limited pachymeningeal disease is permitted)
Multiple sclerosis
Trial design
Treatments tested in this trial
- Targeting All Brain Metastases
Treatment groups
100 Participants
are divided into 2 treatment groupsSponsors and collaborators
British Columbia Cancer Agency
Lead sponsor
Varian Medical Systems
Collaborator
Source ClinicalTrials.gov