About this trial
Traumatic brain injury (TBI) and post-traumatic stress disorder (PTSD) are common combat-related conditions that can result in impairments in cognition, including memory, attention and multi-tasking. There are few effective interventions to improve cognition in Veterans with cognitive impairment due to these conditions. Non-invasive brain stimulation techniques, like transcranial direct current stimulation (tDCS), can be used to stimulate activity in areas of the brain to optimize recovery and rehabilitation. In this study, the investigators are conducting a randomized controlled trial of tDCS to improve cognitive function in Veterans with cognitive impairment due to co-morbid TBI and PTSD. TDCS is remotely administered and paired with cognitive training.
Eligibility criteria
Qualifiers
History of chronic mTBI as measured by Ohio State University Traumatic Brain Injury Identification Method
mTBI occurred > 5 years prior to study enrollment
History of PTSD with symptoms within the last month as confirmed PTSD Checklist (past month) score greater than or equal to 33,
Cognitive impairment as defined by telephone Montreal Cognitive Assessment < 19
Disqualifiers
Skin lesions at the stimulation site that may increase conductance
Metallic objects in the face or head (e.g. braces, fillings, implants)
Pregnancy/lactation or planning to become pregnant during study
History of other significant neurological disorders including seizure disorder, central nervous system tumors, stroke, cerebral aneurysm
Trial design
Treatments tested in this trial
- Transcranial direct current stimulation (tDCS)
- Cognitive training