Remotely Administered tDCS to Improve Cognitive Function in Veterans With mTBI and PTSD Principal Investigator

Trial statusNot yet recruiting
Trial phasePhase 2
Trial typeInterventional
Biological sexAll
Age20-75
SponsorVA Office of Research and Development

About this trial

Traumatic brain injury (TBI) and post-traumatic stress disorder (PTSD) are common combat-related conditions that can result in impairments in cognition, including memory, attention and multi-tasking. There are few effective interventions to improve cognition in Veterans with cognitive impairment due to these conditions. Non-invasive brain stimulation techniques, like transcranial direct current stimulation (tDCS), can be used to stimulate activity in areas of the brain to optimize recovery and rehabilitation. In this study, the investigators are conducting a randomized controlled trial of tDCS to improve cognitive function in Veterans with cognitive impairment due to co-morbid TBI and PTSD. TDCS is remotely administered and paired with cognitive training.

Eligibility criteria

Qualifiers

History of chronic mTBI as measured by Ohio State University Traumatic Brain Injury Identification Method

mTBI occurred > 5 years prior to study enrollment

History of PTSD with symptoms within the last month as confirmed PTSD Checklist (past month) score greater than or equal to 33,

Cognitive impairment as defined by telephone Montreal Cognitive Assessment < 19

Disqualifiers

Skin lesions at the stimulation site that may increase conductance

Metallic objects in the face or head (e.g. braces, fillings, implants)

Pregnancy/lactation or planning to become pregnant during study

History of other significant neurological disorders including seizure disorder, central nervous system tumors, stroke, cerebral aneurysm

Trial design

Treatments tested in this trial

  • Transcranial direct current stimulation (tDCS)
  • Cognitive training

Treatment groups

46 Participants
are divided into 2 treatment groups