Replacing Invasive Cystoscopy With Urine Testing for Non-muscle Invasive Bladder Cancer Surveillance

Trial statusRecruiting
Trial phasePhase 2
Trial typeInterventional
Biological sexAll
Age18+
SponsorWhite River Junction Veterans Affairs Medical Center

About this trial

The purpose of this research is to determine whether bladder cancer monitoring can be improved by replacing some cystoscopy procedures with urine testing. Specifically, this study examines whether there are any differences in urinary symptoms, discomfort, number of invasive procedures, anxiety, complications, cancer recurrence or cancer progression when some cystoscopy procedures are replaced with urine testing.

Eligibility criteria

Qualifiers

Aged 18 years or older

multifocal low grade non-invasive urothelial carcinoma of any size

solitary low grade non-invasive urothelial carcinoma greater than 3cm in size

recurrent low grade non-invasive urothelial carcinoma

Disqualifiers

History of total cystectomy of the bladder.

History of urinary diversion (e.g., neo-bladder, colon pouch, or ileal conduit).

History of muscle-invasive bladder tumor.

Pregnancy or lactation.

Trial design

Treatments tested in this trial

  • Cystoscopy
  • Bladder EpiCheck urine test
  • Xpert Bladder Cancer Monitor urine test

Treatment groups

240 Participants
are divided into 3 treatment groups

Sponsors and collaborators

White River Junction Veterans Affairs Medical Center

Lead sponsor

National Cancer Institute (NCI)

Collaborator

University of Texas Southwestern Medical Center

Collaborator

Medical University of South Carolina

Collaborator