•This is a randomized, open-label, multi-center, phases 2 and phase 3 trial to evaluate the efficacy and safety of SBRT combined with Camrelizumab and Apatinib as conversion therapy versus Camrelizumab combined with Apatinib as first-Line therapy for unresectable hepatocellular carcinoma.
Signed Informed Consent Form (ICF).
Aged 18 years or older.
Hepatocellular carcinoma confirmed by histology/cytology. Cirrhosis meets the clinical diagnostic criteria for hepatocellular carcinoma of the American Association for the Diagnosis of Liver Diseases (AASLD).
Barcelona Clinic Liver Cancer stage B or C disease, which was not amenable to radical surgery.
Known hepatocholangiocarcinoma, sarcomatoid HCC, mixed cell carcinoma and lamellar cell carcinoma; other active malignant tumor except HCC within 5 years or simultaneously.
Existence of active autoimmune disease or history of autoimmune disease and may relapse.
Patients with innate or acquired immune deficiency (e.g., HIV infection).
Known allergies to study drugs or excipients.
Sun Yat-sen University
Lead sponsor
First Affiliated Hospital, Sun Yat-Sen University
Sponsor institution