Sex Differences in Neurobehavioral Response to THC
ConditionCannabis Use Disorder
Trial statusRecruiting
Trial phasePhase 2
Trial typeInterventional
Biological sexAll
Age21-45
SponsorMedical University of South Carolina
About this trial
This study investigates sex differences in reward processing following acute THC administration in adults with cannabis use disorder (CUD). Using multimodal neuroimaging (MRS and fMRI), the study will assess glutamate levels in the nucleus accumbens and striatal BOLD response to monetary reward anticipation. Participants will complete two counterbalanced dosing sessions (oral THC 40 mg vs. placebo).
Eligibility criteria
Qualifiers
Age 21-45
DSM-5 criteria for CUD
Cannabis use ≥4 days/week
THC-positive urine
Disqualifiers
Lifetime psychotic or bipolar disorder
Recent drug use other than cannabis
Current psychotropic medication
Treatment-seeking for SUD
Trial design
Treatments tested in this trial
- Dronabinol
- Placebo
Treatment groups
40 Participants
are divided into 2 treatment groupsSponsors and collaborators
Medical University of South Carolina
Lead sponsor
National Institutes of Health (NIH)
Collaborator
National Institute on Drug Abuse (NIDA)
Collaborator
Source ClinicalTrials.gov