The purpose of this study is to evaluate the effects of adding two oral medications (sonrotoclax plus zanubrutinib) to standard of care chimeric antigen receptor (CAR-T) cell therapy in participants with mantle cell lymphoma.
Have histologically confirmed mantle cell lymphoma that is relapsed or refractory after at least one prior line of systemic therapy
Eligible for and planned to receive Health Canada approved CAR-T.
Have a formalin fixed paraffin embedded tumour tissue block available and must have provided informed consent for the release of the block.
Presence of radiologically documented disease.
• Participants on active anticancer therapy for other advanced or metastatic malignancies.
Concurrent treatment with other anti-cancer therapy
Serious illnesses or medical conditions which would not permit the participant to be managed according to the protocol.
Known hypersensitivity to the study drug(s) or their components.
Canadian Cancer Trials Group
Lead sponsor
BeOne Medicines
Collaborator