The goal of this study is to evaluate the feasibility and effectiveness of same-day radiation planning and treatment. The study will shorten the time interval between radiation planning (radiation mapping) and radiation treatment. The intent of this shorter time interval is to increase the likelihood that the brain metastases being treated remain fully within the high-dose radiation fields.
Participants will be randomized to receive brain-directed stereotactic radiation with a 1mm margin or 0mm margin, have their simulation/radiation planning imaging on the same day that brain-directed stereotactic radiation is delivered, and have repeat simulation/radiation planning scans during the course of treatment if more than 2-3 days have elapsed since the most recent scans.
Growth of 1.0mm per week or more, on average, based on the two most recent brain MRIs preceding study enrollment
Abutment, to within 1.0cm, of a region of intracranial edema
Proximity (within 5.0cm) to a surgical cavity created within 30 days of enrollment
Proximity (within 5.0cm) to another source of physical displacement
Participants who cannot tolerate a brain MRI
Patients who cannot receive gadolinium
Participants with end stage renal disease
Participants with widespread, definitive leptomeningeal disease
Ayal A. Aizer, MD
Lead sponsor
Brigham and Women's Hospital
Sponsor institution
Varian, a Siemens Healthineers Company
Collaborator