This study aims to evaluate the effects of a dual Bifidobacterium longum probiotic formulation (dipro-O and dipro-X) on sleep quality, stress responses, and gut microbiota stability in healthy adults during short-term travel. Using a randomized, double-blind, placebo-controlled design, the study investigates whether probiotic supplementation can enhance sleep resilience, buffer stress, and modulate microbiome and physiological responses under travel-related environmental changes.
Willing to participate in this study and able to provide written informed consent before any study procedures are initiated.
Able and willing to comply with all study procedures as required by the protocol, including continuous wearable device use, saliva and stool sample collection, and completion of questionnaire assessments.
Willing to accept randomization and group allocation as determined by the study protocol.
Known use of antibiotics or systemic corticosteroids within 4 weeks prior to enrollment.
Use of probiotic supplements within 4 weeks prior to enrollment.
Planned use of any probiotic supplements during the study period.
Known history or current presence of major endocrine disorders, active inflammatory bowel disease or other severe gastrointestinal diseases, or severe sleep disorders requiring treatment adjustment.
Min-Tze LIONG
Lead sponsor
Universiti Sains Malaysia
Sponsor institution
The Hong Kong Polytechnic University
Collaborator