Participants will be scheduled for primary cytoreductive surgery as part of their standard care. Before surgery, participants will be assigned by chance to a study group. Depending on which group they are in, they will receive either acute normovolemic hemodilution/ANH during surgery or standard surgical management during surgery. The researchers think acute normovolemic hemodilution/ANH may decrease the need for allogenic blood transfusion/ABT in people having primary cytoreductive surgery.
Adults (≥18 years)
BLOODS score ≥2 as calculated by surgeon
High preoperative suspicion (or diagnosis) of advanced primary epithelial ovarian, fallopian tube, or primary peritoneal carcinoma (stage IIIC or IV), as determined by CT or MRI of the abdomen/pelvis
Planned for exploratory laparotomy and primary or interval cytoreductive surgery
A history of active coronary artery disease
A history of cerebrovascular disease
A history of congestive heart failure
A history of uncontrolled hypertension