Study of Adebrelimab With Chemotherapy, Endoscopy and Sequential Chemoradiotherapy In Inoperable Esophageal Cancer

Trial statusNot yet recruiting
Trial phasePhase 2
Trial typeInterventional
Biological sexAll
Age18-75
SponsorShanghai Zhongshan Hospital

About this trial

Evaluating the efficacy and safety of PD-L1 (Programmed Death-L1)antibody combined with endoscopy and radiotherapy for inoperable cT1b-2 (clinical stage tumor 1b-2) esophageal squamous cell carcinoma

Eligibility criteria

Qualifiers

Signed written informed consent to voluntarily enroll in the study

Age 18-75 years

Histologically or cytologically confirmed squamous esophageal cancer of the thoracic segment

Staging of clinical tumor stage T1b-2N0M0 (according to American Joint Committee on Cancer 8th edition) as judged by the investigator

Disqualifiers

Tumour-related criteria Patients with non-squamous oesophageal cancer Staging not consistent with clinical tumor stage T1b~2N0M0 Other malignancies diagnosed within 5 years prior to first use of study drug, except cured carcinoma in situ of the uterine cervix, basal or squamous cell skin cancers, limited prostate cancer treated with radical surgery, and ductal carcinoma in situ treated with radical surgery

New York Heart Association class 2 or higher heart failure;

unstable angina pectoris;

myocardial infarction within 1 year;

Trial design

Treatments tested in this trial

  • Adebrelimab injection
  • Albumin-Bound Paclitaxel
  • Carboplatin injection

Treatment groups

42 Participants
are divided into 1 treatment group

Locations

This trial has no locations

Sponsors and collaborators