The study is a single arm, nonrandomized phase II prospective study, with the goal of investigating the role of screening brain MRIs in neurologically asymptomatic patients with metastatic breast cancer.
Histologic diagnosis of breast cancer with documentation of ER/PR/HER2 status
Radiographic evidence of stage IV extracranial diease having progressed past first line therapy in HR+/HER2- patients
Radiographic evidence of stage IV extracranial disease in TN and HER2+ patients
Age ≥ 18
Prior diagnosis or treatment of brain metastases or leptomeningeal disease
Patients with prior history of non-breast cancer malignancies should have no evidence of disease ≥ 2 years
Neurologic symptoms warranting standard screening brain MRI in the judgement of the treating physician at time of enrollment
Indications warranting brain MRI for other neurologic conditions at time of study entry
H. Lee Moffitt Cancer Center and Research Institute
Lead sponsor
Florida Breast Cancer Foundation
Collaborator