Evaluate the efficacy and safety of ICP-332 in participants with Prurigo Nodularis (PN)
Voluntarily sign informed consent forms before any investigational procedure(s) are performed.
Male or female aged between 18 and 75 years at the time of signing the informed consent.
Clinical diagnosis of PN by a dermatologist for at least 3 months before the Screening visit.
At least 20 pruriginous lesions on the entire body with a bilateral distribution (on both legs, and/or both arms and/or trunk) at both screening and the baseline (Day 1) visits.
Patients with a documented AD severity moderate to severe presence of skin morbidities other than PN and mild AD that may interfere with the assessment of the study outcomes. PN secondary to medications .
Any uncontrolled or serious disease, or any medical, psychological, or surgical condition including relevant laboratory abnormalities at screening that may either interfere with the interpretation of the clinical trial results and/or, in the investigator's judgment, would adversely affect the patient's participation in the study. Active chronic or acute infection participant not suitable for participation, whatever the reason, as judged by the Investigator, including medical or clinical conditions, or participants potentially at risk of noncompliance to study procedures.