This protocol will investigate whether topical application of N-acetyl cysteine (NAC) eye drops decreases oxidative stress and confers cytoprotection in patients with FECD.
Male or female ≥21 years of age at time of surgical evaluation.
Diagnosis of advanced FECD and visually significant cataract
Indication for DMEK (Descemet Membrane Endothelial Keratoplasty) with concurrent cataract surgery
Written informed consent obtained from subject and ability for subject to comply with the requirements of the study.
Pregnant, breastfeeding, or unwilling to practice birth control during participation in the study.
History of prior intraocular surgery in study eye including cataract, glaucoma and/or retina surgery
History of other corneal diseases, such as severe dry eye, corneal scars, pseudophakic bullous keratopathy, corneal degenerations, corneal infections
Use of ocular prescription medications except for lubricants, hyperosmotic agents, or ocular hypotensive agents