Tesamorelin to Improve Functional Outcomes After Peripheral Nerve Injury

Trial statusRecruiting
Trial phasePhase 2
Trial typeInterventional
Biological sexAll
Age18+
SponsorJohns Hopkins University

About this trial

The aim of this clinical trial is to evaluate the efficacy of tesamorelin as a therapy for peripheral nerve injuries. The investigators hypothesize that treatment with tesamorelin will result in faster and more substantial recovery of motor and sensory function following surgical repair of injured peripheral nerves. Patients with upper extremity nerve injuries will be randomly assigned to receive either tesamorelin treatment or no treatment. Assessments for nerve regeneration, muscle function, and sensation will be conducted every three months for a total of 12 months. Outcomes in patients receiving tesamorelin will be compared to those in the untreated group to determine the effectiveness of tesamorelin as a therapeutic intervention for nerve injuries.

Eligibility criteria

Qualifiers

Ulnar nerve laceration at the wrist, repaired primarily

Disqualifiers

Certain cancers (active or in the past)

Uncontrolled diabetes or hypertension

Certain pituitary problems

Oral contraceptives

Trial design

Treatments tested in this trial

  • Tesamorelin 2 Milligrams (MG)

Treatment groups

36 Participants
are divided into 2 treatment groups

Sponsors and collaborators

Johns Hopkins University

Lead sponsor

United States Department of Defense

Collaborator