The Combination of Adebrelimab and TP Regimen for Neoadjuvant Therapy in Patients With Stage IVB Oral Squamous Cell Carcinoma

Trial statusRecruiting
Trial phasePhase 2
Trial typeInterventional
Biological sexAll
Age18-75
SponsorHospital of Stomatology, Wuhan University

About this trial

The goal of this \[type of study:clinical trial\] is to \[learn about\] in \[Clinical IVB stage oral squamous cell carcinoma patients\]. The main question it aims to answer are:

• \[Observing the effectiveness and safety of the combination of Adebrelimab and TP regimen in neoadjuvant therapy for clinical IVB stage oral squamous cell carcinoma patients\] Participants will \[Received treatment with Adebrelimab combined with TP regimen, followed by surgery after 2 cycles of neoadjuvant therapy. After surgery, radiotherapy and chemotherapy combined with immunotherapy were chosen based on the patient\'s condition, with a total follow-up of two years.\].

Eligibility criteria

Qualifiers

Oral squamous cell carcinoma patients diagnosed by histology or cytology;

Has not received any treatment for oral squamous cell carcinoma in the past;

According to the AJCC TNM staging system, stage clinical IVB;

ECOG score: 0-1 points;

Disqualifiers

There are uncontrollable pleural effusion, pericardial effusion, or abdominal effusion that require repeated drainage;

Have a history of allergies to any components of adelbizumab in the past;

Received any other investigational medication within 4 weeks prior to the first use of the investigational medication, or had a half-life of no more than 5 weeks from the last investigational medication;

Simultaneously enroll in another clinical study, unless it is an observational (non intervention) clinical study or an intervention clinical study follow-up;

Trial design

Treatments tested in this trial

  • Adebrelimab

Treatment groups

35 Participants
are divided into 1 treatment group