Journeying along the historic Silk Road exposes travelers to dramatic dietary shifts, unfamiliar microbial environments, and the physical stresses of long-distance travel-all known to disrupt gut health and cause gastrointestinal complaints, including traveler's diarrhea and sleep disturbances. Such disruptions may also elevate the risk of acquiring antibiotic-resistant organisms.
This randomized, double-blind, placebo-controlled trial evaluated whether probiotic supplementation can help maintain gut microbial balance and support traveler well-being during trips to Silk Road regions. In addition to monitoring changes in gut microbiota composition, the study assessed gastrointestinal symptoms, sleep quality, anxiety levels, overall well-being, gut immune markers, functional profiles of the microbiome, and the presence of antibiotic resistance genes.
Generally healthy adults
Scheduled to undertake a short-term round trip (less than 7 days) to abroad
Able to complete study procedures
Willing to take intervention products
Use of antibiotics, probiotics, hormones, immunosuppressants, biologics or JAK inhibitors within four weeks prior to study
Chronic or severe systemic diseases (including cardiovascular, hepatic, renal, malignant or psychiatric disorders)
Uncontrolled parasitic infections
Long-term use of corticosteroids, growth hormone, vitamin B12, lysine or inositol
Universiti Sains Malaysia
Lead sponsor
Shanghai Jiao Tong University School of Medicine
Collaborator