About this trial
This study aims to evaluate whether luspatercept can improve the efficacy and safety of anemia treatment in patients with hematologic malignancies after allogeneic hematopoietic stem cell transplantation.
Eligibility criteria
Qualifiers
1. Diagnosis of malignant hematological tumors and undergoing allogeneic hematopoietic stem cell transplantation.
2. Expected survival after transplantation exceeds 1 month.
3. Age 18-60 years.
4. Hemoglobin ≤60 g/L on day 0 after transplantation.
Disqualifiers
1. Uncontrolled infection at the time of enrollment, or requiring mechanical ventilation or hemodynamic instability;
2. Severe organic damage: hepatic or renal impairment;
3. Occurrence of any of the following within 6 months prior to the study: myocardial infarction, severe/unstable angina pectoris, congestive heart failure, or cerebrovascular accident, including transient ischemic attack;
4. Presence of psychiatric disorders or other conditions that may compromise compliance with study treatment and monitoring requirements. Failure to sign the informed consent form;
Trial design
Treatments tested in this trial
- Luspatercept