The purpose of this study is verify the efficacy and safety of Human Umbilical Cord Mesenchymal Stem Cells (UC-MSC) therapy for patients with Osteoarthritis, and in addition, provide basis for exploring the treatment regimen of UC-MSC therapy in different degree of cartilage defect disease
Diagnosis of Knee Osteoarthritis by Kellgren and Lawrence Grading Scale, classified with Grade 2-3
Confirm with cartilage injury,articular cartilage part or full-thickness injury, by MR (Magnetic Resonance)
Age <70, no serious organ dysfunction
Over 2 years knee pain or no very effective with conservative treatments
Refuse to sign the consent form, or cannot keep follow-up visit
Age >70; Age <70, but with multiple organ failure
Unstable vital signs (breath, blood pressure, pulse)
Combined with knee ligament (anterior and the posterior cruciate ligament, medial and lateral collateral ligament) rupture, laxity, etc.