The Use of Propranolol in the Perioperative Period of Resectable Gastrointestinal Tumors
ConditionGastrointestinal Tumors
Trial statusRecruiting
Trial phasePhase 2
Trial typeInterventional
Biological sexAll
Age18-65
SponsorHuashan Hospital
About this trial
In this study, perioperative propranolol β-blockade was administered to patients with surgically resectable primary gastrointestinal tumors to explore the safety, efficacy, and alleviation of perioperative psychological stress. At the same time, a multi-omics study was conducted using clinical samples to explore the activation of anti-tumor immune response and its mechanism.
Eligibility criteria
Qualifiers
Surgically resectable primary gastric cancer and colorectal cancer;
Age greater than 18 years old and less than 65 years old;
Negative pregnancy test for women of childbearing age;
ECOG score ≤2;
Disqualifiers
Pathological sinus node syndrome;
Sinus bradycardia (less than 60 beats/minute);
First, second or third degree AV block;
Resting blood pressure less than 100/60 mmHg;
Trial design
Treatments tested in this trial
- propranolol (beta-blocker used treat high blood pressure)
Treatment groups
40 Participants
are divided into 1 treatment groupSponsors and collaborators
Source ClinicalTrials.gov