This is a Phase II, Open-label, Multicentre Study of Zanubrutinib-containing Regimens in Patients With Newly Diagnosed Mantle Cell Lymphoma

Trial statusNot yet recruiting
Trial phasePhase 2
Trial typeInterventional
Biological sexAll
Age18+
SponsorHenan Cancer Hospital

About this trial

This is a phase II, open-label, multicentre study of Zanubrutinib-containing regimens in patients with newly diagnosed mantle cell lymphoma.

Eligibility criteria

Qualifiers

Voluntary participation in clinical study; Fully understand and understand the study and sign the informed consent form (ICF);Willingness to follow and ability to complete all study steps

Histopathologically confirmed mantle cell lymphoma according to the 5th edition of the World Health Organization (WHO),previous untreatment for mantle-cell lymphoma (MCL)

The elderly group ≥65 years old;The young group was ≥18 years old and < 65 years old.

ECOG Performance Status 0-3

Disqualifiers

The presence of other tumors could affect the study medication or interfere with the results;

Patients require treatment with strong or moderate CYP3A inhibitors;

Pregnant or lactating women;

Known to be allergic to the test drug ingredients;

Trial design

Treatments tested in this trial

  • Zanubrutinib,Obinutuzumab
  • Zanubrutinib and R-BAC

Treatment groups

41 Participants
are divided into 2 treatment groups

Locations

This trial has no locations

Sponsors and collaborators