Thymalfasin and Recombinant Human IL-2 Injections in Treating Lymphocytopenia for Patients With Malignant Hematological Tumors

Trial statusRecruiting
Trial phasePhase 2
Trial typeInterventional
Biological sexAll
Age18+
SponsorThe First Affiliated Hospital of Xiamen University

About this trial

To evaluate the efficacy and safety of Thymalfasin for injection in combination with Recombinant Human Interleukin-2 Injections in the treatment of lymphocytopenia in patients with malignant hematological tumors

Eligibility criteria

Qualifiers

Patients with histologically confirmed myeloid, B lymphocyte, and plasma cell-derived malignant hematological tumors.

Lymphocyte count ≤ 0.8×109/L or CD4+T cell count ≤ 0.35×109/L.

Age ≥ 18 years, both male and female, with an expected survival period of more than 3 months.

Estimated creatinine clearance rate ≥ 30 mL/min.

Disqualifiers

Active autoimmune disease.

Patients considered to have a malignant T-cell clone.

Within 8 days after chemotherapy for lymphoma and within 14 days after chemotherapy for AML.

Tumor involvement in the bone marrow leading to hematopoietic suppression (neutrophils <1.0×10^9/L, HB<70g/L, PLT<50×10^9/L).

Trial design

Treatments tested in this trial

  • Thymalfasin for injection in combination with Recombinant Human Interleukin-2 Injections
  • Recombinant Human Interleukin-2 Injections

Treatment groups

50 Participants
are divided into 3 treatment groups