Topical Metformin Versus Topical Ketotifen in Melasma Treatment
ConditionMelasma
Trial statusNot yet recruiting
Trial phasePhase 2
Trial typeInterventional
Biological sexAll
Age18-60
SponsorAssiut University
About this trial
The study aims to evaluate and compare the efficacy and safety of a new formulation of topical metformin (nanoparticles) versus topical ketotifen (nanoparticles), both alone and combined with micro-needling, for the treatment of melasma. It is a double-blinded, randomized, split-face controlled clinical study involving 102 female patients diagnosed with bilateral melasma.
Eligibility criteria
Qualifiers
Female adults of 18 years and above with bilateral melasma .
Clinical diagnosis of melasma.
Mental capacity to give informed consent.
Disqualifiers
Pregnant or nursing women.
Current use of hormonal birth control medication or any hormonal therapy.
Current or previous treatment by depigmenting agents within 3 months
History of laser or MN to the face within 3 months of study enrollment.
Trial design
Treatments tested in this trial
- Micro-Needling Combined with ketofin and metformin
- ketofin and metformin Alone
Treatment groups
60 Participants
are divided into 2 treatment groupsLocations
Sponsors and collaborators
Source ClinicalTrials.gov