This trial is a prospective, open-label, single-center, split face randomized controlled study comparing 1.5% topical Ruxolitinib cream twice daily (BD) to aqueous cream in treating non-segmental vitiligo (NSV) of the face and neck in patient previous failed to respond to topical tacrolimus 0.1%. Aqueous cream twice daily application will be used as control group treatment. Patients with stable NSV at least 0.5% of their total body surface area (BSA) on the face and neck, as determined by the fingertip method, are screened. Recruited subjects will be asked to review their impression of change of their lesion by the end of the study using a 7-point scale.
18 - 85 year old
Have a clinical diagnosis of stable non-segmental vitiligo
Depigmentation including at least 0.5% of the BSA on the face and neck
Previously treated with topical tacrolimus 0.1% BD for at least 3 months without significant response
Patients who refuse to give consent
Presence of different vitiligo types or other skin depigmentation conditions like piebaldism or leprosy, etc.
History of using depigmentation treatments other than hydroquinone for vitiligo or pigmentation issues
Any skin condition affecting study participation, active skin infections one week before the study starts, issues impacting vitiligo evaluation, or serious health problems limiting involvement or increasing risk