Transcranial Magnetic Stimulation + Language Therapy to Treat Mild Aphasia
Trial statusRecruiting
Trial phasePhase 2
Trial typeInterventional
Biological sexAll
Age40-85
SponsorUniversity of Pennsylvania
About this trial
The goal of this clinical trial is to determine if Transcranial Magnetic Stimulation (TMS) combined with Speech-Language Therapy (SLT) is an effective treatment for mild aphasia in persons with chronic stroke.
The main questions this study aims to answer are:
1. Can TMS combined with SLT improve conversational speech and comprehension? 2. Can we identify specific behavioral and biological characteristics that would benefit most from the TMS and SLT treatment?
Researchers will compare real TMS to sham (fake) TMS to see whether TMS can treat post-stroke mild aphasia.
Participants will:
* Complete a screening and medical intake to determine eligibility * Undergo a MRI * Participate in 10 consecutive sessions (Monday-Friday) of TMS and SLT treatment * Complete follow-up assessments 2 and 4 months after treatment
Eligibility criteria
Qualifiers
Left Hemisphere stroke
Stroke occurred more than 6 months ago
Mild Aphasia (WAB AQ score > 85)
Proficient in English
Disqualifiers
Ongoing substance or alcohol abuse
Other neurological disorders, beside stroke (i.e. dementia, traumatic brain injury, multiple sclerosis)
Active psychiatric disorders (i.e. bipolar disorder, schizophrenia)
Pacemaker or cardiac defibrillator
Trial design
Treatments tested in this trial
- Transcranial Magnetic Stimulation (TMS)
- Speech-Language Therapy (SLT)
Treatment groups
24 Participants
are divided into 2 treatment groupsSponsors and collaborators
University of Pennsylvania
Lead sponsor
Temple University
Collaborator
National Institute on Deafness and Other Communication Disorders (NIDCD)
Collaborator
Source ClinicalTrials.gov