Transcutaneous Auricular Vagus Nerve Stimulation in Dry Eye Disease
ConditionDry Eye Disease
Trial statusRecruiting
Trial phasePhase 2
Trial typeInterventional
Biological sexAll
Age18-65
SponsorBeijing Tongren Hospital
About this trial
Objective: To evaluate the effect of transcutaneous auricular vagus nerve stimulation (taVNS) for the patients with dry eye disease with meibomian gland dysfunction.
Methods: We enrolled 256 patients at Beijing Tongren Hospital. Patients completed questionnaires at baseline, 1 month, 3 months, and 6 months.OSDI score, TBUT, Schirmer I, tCFS, MGD score, and psychological status to evaluate the therapeutic effects. A difference of P \< 0.05 was considered statistically significant.
Eligibility criteria
Qualifiers
Age >=18 and Age <=75.
Clinical diagnosis of dry eye disease.
Disqualifiers
History of depression, tumors, thyroid disease, diabetes, cardiac diseases.
History of phthalmology surgery.
Pregnant or lactating women.
Trial design
Treatments tested in this trial
- Transcutaneous Auricular Vagus Nerve Stimulation
- Hyaluronic acid eye drops
Treatment groups
128 Participants
are divided into 2 treatment groupsSponsors and collaborators
Source ClinicalTrials.gov