Transdermal Estrogen in Women With Anorexia Nervosa

ConditionAnorexia Nervosa

Trial statusRecruiting

Trial phasePhase 2

Trial typeInterventional

Biological sexFemale

Age19-45

SponsorPouneh K. Fazeli, MD

About this trial

Randomized, placebo-controlled study investigating the use of physiologic, transdermal estrogen for low bone mass in adult women with anorexia nervosa.

Eligibility criteria

Qualifiers

Female

19-45 years of age

DSM-5 psychiatric criteria for anorexia nervosa

<85% of ideal body weight as defined by the 1983 Metropolitan Life Insurance Height and Weight Tables

Disqualifiers

Diseases known to affect bone metabolism, including untreated thyroid dysfunction, vitamin D deficiency, Cushing's syndrome, diabetes mellitus or renal insufficiency (eGFR < 60)

Personal history of venous or arterial clot

History of stroke or myocardial infarction

History of hypercoagulable disorder

Trial design

Treatments tested in this trial

Transdermal estrogen
Placebos

Treatment groups

66 Participants

are divided into 2 treatment groups

Sponsors and collaborators

Pouneh K. Fazeli, MD

Lead sponsor

University of Pittsburgh

Sponsor institution

Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)

Collaborator

Source ClinicalTrials.gov