CHIMOVIP is a study to determine the best therapeutic strategy in patient with ovarian advanced cancer.
Histologically confirmed advanced (FIGO stage III or IV) invasive epithelial ovarian cancer, primary peritoneal cancer, or fallopian-tube cancer. Pleural cytology has to be performed in patients with pleural effusion.
Initial intervention : debulking surgery or diagnostic surgery in the 3 weeks before inclusion
Age ≥18 and < 75 years old.
Eastern Cooperative Oncology Group (ECOG) performance status ≤ 2 before surgery (ECOG ≤ 1 and Lee score < 6 in patients > 70 years old).
FIGO stage IV extra-abdominal disease, with the exception of lymph nodes and pleural invasion.
Patient having received previous chemotherapy for ovarian cancer.
Left ventricular ejection fraction < 50% before chemotherapy initiation
Other invasive cancer in the past 5 years (baso- and spinocellular cutaneous carcinoma with complete resection are accepted)
Groupe Hospitalier Diaconesses Croix Saint-Simon
Lead sponsor
GERCOR - Multidisciplinary Oncology Cooperative Group
Collaborator