UCSD Image-Guided Cognitive-Sparing Radiosurgery for Brain Metastases
Trial statusRecruiting
Trial phasePhase 2
Trial typeInterventional
Biological sexAll
Age18+
SponsorJona Hattangadi-Gluth
About this trial
In this proposal, the investigators introduce advanced diffusion and volumetric imaging techniques along with innovative, automated image parcellation methods to identify critical brain regions, incorporate into cognitive-sparing SRS, and analyze biomarkers of radiation response. This work will advance the investigators' understanding of neurocognitive changes after brain SRS and help create interventions that preserve cognitive-function in brain metastases patients.
Eligibility criteria
Qualifiers
Patients 18 years or older
One to three brain metastases targets, all smaller than 3 cm in diameter (intact or resected tumor bed)
Eastern cooperative Oncology Group (ECOG) performance status 0-2 (score of 0, no symptoms; 1, mild symptoms; 2, symptomatic, <50% in bed during the day)
Ability to answer questions and follow commands via neurocognitive testing
Disqualifiers
Pregnant or nursing women
Women of childbearing potential unwilling to use adequate contraception
Inability to complete a magnetic resonance imaging scan with contrast
Tumor directly invading the critical area to be spared (for example a patient with tumor invading a critical white matter tract; ineligible for cognitive-sparing)
Trial design
Treatments tested in this trial
- Cognitive Sparing Brain Stereotactic Radiosurgery (SRS)
Treatment groups
60 Participants
are divided into 1 treatment groupSponsors and collaborators
Jona Hattangadi-Gluth
Lead sponsor
University of California, San Diego
Sponsor institution
National Institutes of Health (NIH)
Collaborator
National Cancer Institute (NCI)
Collaborator
Source ClinicalTrials.gov