Understanding the Role of the Locus Coeruleus in Insomnia
ConditionInsomnia
Trial statusNot yet recruiting
Trial phasePhase 2
Trial typeInterventional
Biological sexAll
Age30-65
SponsorWoolcock Institute of Medical Research
About this trial
This research project aims to better understand the neurobiological mechanistic underpinnings of insomnia disorder. The main question is whether cortical hyperarousal in individuals with insomnia disorder, measured by electroencephalograhic (EEG) infraslow oscillation coupling of sigma power during non-rapid eye movement (NREM) sleep and theta power during rapid eye movement (REM) sleep, is related to locus coeruleus activity.
Eligibility criteria
Qualifiers
Diagnosis of insomnia disorder (DSM-5-TR)
Insomnia severity index (ISI) score ≥15
Able to provide informed consent
Fluent English literacy
Disqualifiers
Medically diagnosis of sleep disordered breathing (i.e. sleep apnea) or sleep or circadian disorder other than insomnia
Uncontrolled psychiatric disorders
High dependence on medical care
History of, or current suicide ideation (Patient Health Questionnaire (PHQ-9) questionnaire)
Trial design
Treatments tested in this trial
- Dexmedetomidine
- Placebo
Treatment groups
15 Participants
are divided into 2 treatment groupsSponsors and collaborators
Source ClinicalTrials.gov