Use of Vasopressin in Patients at High Risk of Acute Kidney Injury Admitted to the ICU

ConditionCritical Illness

Trial statusRecruiting

Trial phasePhase 2

Trial typeInterventional

Biological sexAll

Age18+

SponsorHospital do Coracao

About this trial

Renal dysfunction is a frequent complication in patients admitted to intensive care units (ICUs), associated with high morbidity and mortality. Current therapeutic options to prevent this condition are limited and lack robust scientific evidence. This pilot study consists of a multicenter, blinded, randomized clinical trial, unprecedented in the literature to date, aiming to fill this knowledge gap and offer new therapeutic perspectives to improve renal outcomes in critically ill patients admitted to the ICU.

Eligibility criteria

Qualifiers

Adult patients (≥18 years old);

Admitted to intensive care units;

Predicted risk of acute kidney injury calculated based on clinical and laboratory data at ICU admission and is considered eligible if the value in the calculator is equal or greater than 5 points;

Disqualifiers

Time since admission to the ICU greater than 24 hours;

Use of vasopressors at the time of inclusion;

MAP >90 mmHg;

Hyponatremia (<130 mmol/L);

Trial design

Treatments tested in this trial

Vasopressin
0,9% saline solution

Treatment groups

60 Participants

are divided into 2 treatment groups

Sponsors and collaborators

Hospital do Coracao

Lead sponsor

Source ClinicalTrials.gov