Using Xe MRI to Guide Radiation Therapy for Lung Cancer
ConditionImaging Techniques
Trial statusRecruiting
Trial phasePhase 2
Trial typeInterventional
Biological sexAll
Age18-80
SponsorSean Fain
About this trial
The purpose of this research study is to explore using MRI scans with xenon to better image lung function, how lung function changes after radiation therapy, and to guide radiation therapy away from parts of the lung that have good function. This project is foundational to performing additional studies to establish if novel MRI imaging can serve as a guidance tool for lung cancer radiation treatment.
Eligibility criteria
Qualifiers
Aged 18-80 years
Willing and able to provide informed consent and adhere to visit/protocol schedules (Consent must be given before any study procedures are performed.)
Clinical diagnosis of lung cancer made by a board-certified oncologist with intent to treat with stereotactic body radiation therapy. We will not exclude individuals based on cancer type or severity of disease with the exception of the below criteria
Disqualifiers
Subject is less than 18 years old or incarcerated
MRI is contraindicated based on responses to MRI screening questionnaire
Subject is pregnant or lactating
Resting oxygen saturation <90% on supplemental oxygen
Trial design
Treatments tested in this trial
- Xenon MRI
- Pulmonary Function Testing
- Quality of Life Questionnaire
- Medical Research Council Dyspnea score
- St. George's Respiratory Questionnaire
- Blood Biomarkers
Treatment groups
15 Participants
are divided into 2 treatment groupsSponsors and collaborators
Sean Fain
Lead sponsor
University of Iowa
Sponsor institution
Source ClinicalTrials.gov