The optimal vasopressor for ensuring organ blood flow and tissue oxygen delivery during surgery remains undetermined. This study aim to compare the effects of noradrenaline vs. phenylephrine infusion on blood flow and oxygen delivery to the brain and various other organs in anesthetized neurosurgical patients.
Clinical diagnosis of supratentorial malignant or non-malignant brain tumors. Preferably 3 cm or larger( measured as the largest diameter in any plane on MRI).
Scheduled for elective supratentorial craniotomy.
Patients aged between 18 and 75 years.
American Society of Anesthesiologists status 1-3
History of allergy or intolerance to one of the study medications.
Active treatment with monoamine oxidase inhibitors.
An American Society of Anesthesiologists (ASA)physical status IV-VI.
Pregnancy or breastfeeding.