VCA Regimen Followed by D-MAG Regimen on the Treatment of Elderly Patients With Newly Diagnosed Acute Myeloid Leukemia (AML)

Trial statusRecruiting
Trial phasePhase 2
Trial typeInterventional
Biological sexAll
Age60+
SponsorThe First Affiliated Hospital of Xiamen University

About this trial

The purpose of this study is to evaluate the safety and efficacy of Venetoclax Combining Chidamide and Azacitidine (VCA) Followed by D-MAG Regimen on the Treatment of Elderly Patients With Newly Diagnosed Acute Myeloid Leukemia (AML)

Eligibility criteria

Qualifiers

1) Histologically confirmed acute myeloid leukemia (non-M3). Treatment-na?ve and unable to receive standard cytarabine and anthracycline induction regimens due to age or comorbidities or patient preference.

Disqualifiers

1)Acute promyelocytic leukemia (APL) and low risk cytogenetics such as t(8;21), inv(16) or t(16;16).

Trial design

Treatments tested in this trial

  • Venetoclax Combining Chidamide and Azacitidine (VCA) regimen followed by dicitabine combined with liposome mitoxantrone, cytarabine, and G-CSF (D-MAG) regimen

Treatment groups

66 Participants
are divided into 1 treatment group

Sponsors and collaborators

The First Affiliated Hospital of Xiamen University

Lead sponsor

Chipscreen Biosciences, Ltd.

Collaborator

CSPC Pharmaceutical Group Limited

Collaborator

Fujian Provincial Hospital

Collaborator

Fujian Cancer Hospital

Collaborator

Zhangzhou manicipal hospital of Fujian Province

Collaborator

Jieyang People's Hospital

Collaborator

Huizhou Municipal Central Hospital

Collaborator