Vertebrobasilar Dolichoectasia Treatment With Amiloride
ConditionVertebrobasilar Dolichoectasia
Trial statusNot yet recruiting
Trial phasePhase 2
Trial typeInterventional
Biological sexAll
Age18+
SponsorHuashan Hospital
About this trial
The aim of this pilot study is to assess the efficacy of amiloride in reducing wall enhancement in vertebrobasilar dolichoectasia(VBD) on high-resolution magnetic resonance vessel wall imaging(HR-VWI) via anti-inflammatory mechanisms, clarify the efficacy of amiloride in delaying the progression of VBD, evaluate the safety of amiloride in the treatment of VBD.
Eligibility criteria
Qualifiers
Age≥18 years, any gender;
Patients with VBD confirmed by DSA/CTA/MRA;
No history of VBD rupture and no surgical treatment for VBD;
mRS<4;
Disqualifiers
History of malignant tumors, systemic lupus erythematosus, or gout;
Pregnancy or lactation;
Amiloride or sulfonamide allergy;
Hydrocephalus requiring urgent surgical intervention or respiratory failure requiring life support treatment;
Trial design
Treatments tested in this trial
- Amiloride hydrochlorothiazide
Treatment groups
6 Participants
are divided into 1 treatment groupSponsors and collaborators
Source ClinicalTrials.gov