This study is conducted to investigate whether modified chemoradiotherapy with elective nodal irradiation reduces the locoregional recurrence that cannot be completely resected by salvage endoscopic resection and preserve esophagus without compromising overall survival.
Histologically proven squamous cell carcinoma, adenosquamous carcinoma, or basaloid cell carcinoma.
All lesions located in the thoracic esophagus. Secondary lesions with an absolute indication for endoscopic resection (EMR/ESD) may not be confined to the thoracic esophagus.
Clinical N0M0 with cervical to abdominal contrast-enhanced CT.
The deepest lesion is diagnosed as cT1b (SM1 / SM2 / SM3) with upper gastrointestinal endoscopy. If it is difficult to differentiate cT1a-MM and cT1b-SM1 clinically, the wall depth is diagnosed as cT1b-SM1.
Simultaneous or metachronous (within 5 years) double cancers, except for intramucosal tumor curable with local therapy.
Active infection requiring systemic therapy.
Fever over 38 degrees Celsius
Female during pregnancy, within 28 days of post parturition, or during lactation. Male who wants a partner's pregnancy.