A Study of Angiotensin-II Receptor Blocker on Cardiovascular Remodeling (VALUE Trial)
Trial statusRecruiting
Trial phasePhase 3
Trial typeInterventional
Biological sexAll
Age18+
SponsorMayo Clinic
About this trial
The purpose of this study is to evaluate the effectiveness and mechanism of action of Losartan in the treatment of coarctation of aorta.
Eligibility criteria
Qualifiers
B/S1 hypertension
SBP 100-139 average based on 3 office measurements.
Age 18 or Older
Previous COA Repair
Disqualifiers
Currently on beta blocker (BB) therapy
Pregnancy/lactating
eGFR<30
Hyperkalemia (serum potassium >5.5mmol/L)
Trial design
Treatments tested in this trial
- Losartan
- Amlodipine
- Placebo
Treatment groups
120 Participants
are divided into 3 treatment groupsSponsors and collaborators
Mayo Clinic
Lead sponsor
National Heart, Lung, and Blood Institute (NHLBI)
Collaborator
Source ClinicalTrials.gov